Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC037
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-08 09:22
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old pacient tbl Madopar 250mg 4x1/2

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 19, 'TN': 15, 'TP': 23, 'FP': 15}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 15, 'TP': 22, 'FP': 15}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 13.9
timePerCircleCoV 0.077172
timePerCircleSlope 0.0114236
meanError 1.58401
tremorFreq 5.95703
tremorRelPower 23.6104
tremorGyroAmpMean 0.0354086
tremorGyroAmpSlope 0.000662796
tremorGyroAmpCoV 0.408954
tremorCoordAmpMean 0.0645284
tremorCoordAmpSlope 0.000368527
tremorCoordAmpCoV 0.383141
tremorAccAmpMean 0.0554127
tremorAccAmpSlope 0.00100687
tremorAccAmpCoV 0.35242
tremorPcRelVar 0.597455
tremorPcX -0.549157
tremorPcY 0.835719

Circle Segment 1

Duration 14.32 s, Accuracy Estimate 1.87 (lower is better)

Circle Segment 2

Duration 13.04 s, Accuracy Estimate 1.425 (lower is better)

Circle Segment 3

Duration 12.92 s, Accuracy Estimate 1.662 (lower is better)

Circle Segment 4

Duration 13.68 s, Accuracy Estimate 1.282 (lower is better)

Circle Segment 5

Duration 13.0 s, Accuracy Estimate 1.506 (lower is better)

Circle Segment 6

Duration 13.36 s, Accuracy Estimate 1.595 (lower is better)

Circle Segment 7

Duration 15.36 s, Accuracy Estimate 1.322 (lower is better)

Circle Segment 8

Duration 13.08 s, Accuracy Estimate 1.514 (lower is better)

Circle Segment 9

Duration 16.0 s, Accuracy Estimate 1.381 (lower is better)

Circle Segment 10

Duration 14.24 s, Accuracy Estimate 2.283 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 52.88
timePerSpiralCoV 0.120579
timePerSpiralSlope -0.0706505
meanError 1.63606
tremorFreq 5.95703
tremorRelPower 23.1119
tremorGyroAmpMean 0.0291284
tremorGyroAmpSlope -0.000467888
tremorGyroAmpCoV 0.438729
tremorCoordAmpMean 0.0449054
tremorCoordAmpSlope -0.000160244
tremorCoordAmpCoV 0.398039
tremorAccAmpMean 0.0386409
tremorAccAmpSlope -0.000220996
tremorAccAmpCoV 0.428698
tremorPcRelVar 0.657795
tremorPcX -0.579883
tremorPcY 0.8147

Spiral Segment 1

Duration 58.68 s, Accuracy Estimate 1.83 (lower is better)

Spiral Segment 2

Duration 58.92 s, Accuracy Estimate 1.624 (lower is better)

Spiral Segment 3

Duration 54.44 s, Accuracy Estimate 1.551 (lower is better)

Spiral Segment 4

Duration 45.8 s, Accuracy Estimate 1.524 (lower is better)

Spiral Segment 5

Duration 46.56 s, Accuracy Estimate 1.652 (lower is better)

Elel

eDurationMean 1.50737
eDurationStd 0.226527
eDurationStdnorm 0.15028
eDurationMedian 1.5175
eDurationQuartdelta 0.32
eDurationQuartdeltanorm 0.210873
eDurationKurt 3.38208
eDurationTrenddiff -0.11
eDurationTrendratio 0.929032
eWidthMean 5.88695
eWidthStd 1.36203
eWidthStdnorm 0.231364
eWidthMedian 5.616
eWidthQuartdelta 2.223
eWidthQuartdeltanorm 0.395833
eWidthKurt 2.34569
eWidthTrenddiff 0.468
eWidthTrendratio 1.08511
eHeightMean 13.3503
eHeightStd 2.68471
eHeightStdnorm 0.201097
eHeightMedian 13.5135
eHeightQuartdelta 3.393
eHeightQuartdeltanorm 0.251082
eHeightKurt 2.42586
eHeightTrenddiff 0.117
eHeightTrendratio 1.0087
eAspectMean 0.451522
eAspectStd 0.105138
eAspectStdnorm 0.232852
eAspectMedian 0.447565
eAspectQuartdelta 0.132323
eAspectQuartdeltanorm 0.295652
eAspectKurt 2.64339
eAspectTrenddiff 0.0253759
eAspectTrendratio 1.05921
eSlantMean -0.0211099
eSlantStd 0.147755
eSlantStdnorm -6.99933
eSlantMedian -0.0337847
eSlantQuartdelta 0.199252
eSlantQuartdeltanorm -5.8977
eSlantKurt 2.69186
eSlantTrenddiff 0.116846
eRtopMean 0.648814
eRtopStd 0.170377
eRtopStdnorm 0.262598
eRtopMedian 0.705903
eRtopQuartdelta 0.196429
eRtopQuartdeltanorm 0.278266
eRtopKurt 3.35487
eRtopTrenddiff 0.117517
eRbotMean 0.729875
eRbotStd 0.266578
eRbotStdnorm 0.365238
eRbotMedian 0.725721
eRbotQuartdelta 0.311688
eRbotQuartdeltanorm 0.429488
eRbotKurt 3.8283
eRbotTrenddiff -0.0960111
eRrightMean 0.839519
eRrightStd 0.0982392
eRrightStdnorm 0.117019
eRrightMedian 0.864584
eRrightQuartdelta 0.156111
eRrightQuartdeltanorm 0.180562
eRrightKurt 2.25814
eRrightTrenddiff 0.0712773
eRleftMean 0.424011
eRleftStd 0.128094
eRleftStdnorm 0.302101
eRleftMedian 0.425495
eRleftQuartdelta 0.171463
eRleftQuartdeltanorm 0.402973
eRleftKurt 4.34543
eRleftTrenddiff -0.0656566
lDurationMean 1.68329
lDurationStd 0.263019
lDurationStdnorm 0.156253
lDurationMedian 1.6625
lDurationQuartdelta 0.315
lDurationQuartdeltanorm 0.189474
lDurationKurt 3.38535
lDurationTrenddiff 0.02
lDurationTrendratio 1.01208
lWidthMean 5.56674
lWidthStd 1.49106
lWidthStdnorm 0.267852
lWidthMedian 5.3235
lWidthQuartdelta 1.755
lWidthQuartdeltanorm 0.32967
lWidthKurt 3.00894
lWidthTrenddiff 1.053
lWidthTrendratio 1.21951
lHeightMean 23.5293
lHeightStd 2.75073
lHeightStdnorm 0.116907
lHeightMedian 23.634
lHeightQuartdelta 3.042
lHeightQuartdeltanorm 0.128713
lHeightKurt 3.22573
lHeightTrenddiff 2.457
lHeightTrendratio 1.11053
lAspectMean 0.235812
lAspectStd 0.0533396
lAspectStdnorm 0.226195
lAspectMedian 0.225553
lAspectQuartdelta 0.0692389
lAspectQuartdeltanorm 0.306974
lAspectKurt 3.43832
lAspectTrenddiff 0.02495
lAspectTrendratio 1.12031
lSlantMean -0.0900818
lSlantStd 0.124196
lSlantStdnorm -1.3787
lSlantMedian -0.0784476
lSlantQuartdelta 0.160654
lSlantQuartdeltanorm -2.04792
lSlantKurt 2.77505
lSlantTrenddiff 0.130997
lRtopMean 0.573247
lRtopStd 0.164499
lRtopStdnorm 0.28696
lRtopMedian 0.582372
lRtopQuartdelta 0.197552
lRtopQuartdeltanorm 0.33922
lRtopKurt 2.73427
lRtopTrenddiff 0.137888
lRbotMean 1.02993
lRbotStd 0.470226
lRbotStdnorm 0.456562
lRbotMedian 0.864469
lRbotQuartdelta 0.754839
lRbotQuartdeltanorm 0.873182
lRbotKurt 2.20989
lRbotTrenddiff -0.649123
lRrightMean 0.815244
lRrightStd 0.101755
lRrightStdnorm 0.124816
lRrightMedian 0.834387
lRrightQuartdelta 0.129633
lRrightQuartdeltanorm 0.155363
lRrightKurt 3.04577
lRrightTrenddiff -0.00621752
lRleftMean 0.466315
lRleftStd 0.214975
lRleftStdnorm 0.461008
lRleftMedian 0.44442
lRleftQuartdelta 0.316373
lRleftQuartdeltanorm 0.711878
lRleftKurt 2.0912
lRleftTrenddiff -0.268489

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.748187
sumTouchScores 26.9347
meanMovementTime 0.528571
numTouches 36
undershootPercentage 13.8889
overshootPercentage 25

FITTS Long Modified

meanTouchScore 0.82867
sumTouchScores 17.4021
meanMovementTime 0.89625
numTouches 21
undershootPercentage 4.7619
overshootPercentage 14.2857

ZigZag

numZigzags 5
timePerZigzagMean 55.056
timePerZigzagCoV 0.192035
timePerZigzagSlope 0.120677
meanError 2.13523
tremorFreq 5.66406
tremorRelPower 18.9892
tremorGyroAmpMean 0.041938
tremorGyroAmpSlope -0.000489465
tremorGyroAmpCoV 0.374278
tremorCoordAmpMean 0.073004
tremorCoordAmpSlope -0.000849373
tremorCoordAmpCoV 0.400143
tremorAccAmpMean 0.100783
tremorAccAmpSlope -0.000278335
tremorAccAmpCoV 0.176756
tremorPcRelVar 0.729487
tremorPcX 0.00471128
tremorPcY 0.999989

ZigZag Segment 1

Duration 42.96 s, Accuracy Estimate 1.685 (lower is better)

ZigZag Segment 2

Duration 47.88 s, Accuracy Estimate 2.027 (lower is better)

ZigZag Segment 3

Duration 53.92 s, Accuracy Estimate 1.953 (lower is better)

ZigZag Segment 4

Duration 60.8 s, Accuracy Estimate 2.39 (lower is better)

ZigZag Segment 5

Duration 69.72 s, Accuracy Estimate 2.621 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 30.48
timePerZigzagCoV 0.198924
timePerZigzagSlope -0.0964567
zigzagHeightMean 74.29
zigzagHeightCoV 0.0373327
zigzagHeightSlope 0.00363605
meanError 0.0512082
tremorFreq 5.95703
tremorRelPower 22.2974
tremorGyroAmpMean 0.0339782
tremorGyroAmpSlope 0.00156907
tremorGyroAmpCoV 0.339362
tremorCoordAmpMean 0.0637815
tremorCoordAmpSlope 0.00314907
tremorCoordAmpCoV 0.303492
tremorAccAmpMean 0.0530364
tremorAccAmpSlope 0.0030801
tremorAccAmpCoV 0.329082
tremorPcRelVar 0.684673
tremorPcX 0.0761449
tremorPcY -0.997097

ZigZag Offset Segment 1

Duration 31.84 s, Accuracy Estimate 0.093 (lower is better)

ZigZag Offset Segment 2

Duration 39.24 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 3

Duration 30.2 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 4

Duration 28.72 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 5

Duration 22.4 s, Accuracy Estimate 0.067 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.865562162155395}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8081673788316173}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}